It will be stressed somewhat when you first get it. Put it wherever you want it provided it's not right by a window. It will get used to its surroundings.
If you don't want it to get bored, get it plenty of cage decorations to explore; just nothing it climb higher than about 6 inches on, as it could fall and get hurt. Leopard geckos are solitary animals and do not require any form of companionship, so your working will not cause depression or boredom. A dull cage may cause boredom though.
Pease do yourself and your leopard gecko a favor by researching the proper set-up and not relying on a pet store to know what is best. Get it's home set-up and make sure all the temperatures are correct before buying the leo. By doing this, you reduce the risk of having to keep making changes to its home that would cause further stress.
As far as handling, some would say that handling stresses leopard geckos out and you should only do it when you absolutely have to. I believe that most leopard geckos will grow to be indifferent about being handled and you can take them out for short periods every once in a while if you wish. After you get your leo, you'll want to give it about two weeks to adjust to the move. Then, you can begin to place your hand in its enclosure and let it approach you. After it becomes comfortable with your hand, you may try letting it walk into your hand and lift it a couple inches off the floor of the enclosure. Do that a few times until it gets comfortable, and then you can begin taking it out of the enclosure. Just be sure to keep it close to the ground so that if it gets spooked it can't fall very far. Some leopard geckos grow to tolerate handling quite quickly while others never really do.
Let me warn you about some common misconceptions about leopard gecko husbandry.
1) A ten gallon aquarium is not sufficient for a leopard gecko. A 20 long will be the smallest acceptable enclosure.
2) Red lights are not a good option for heating leos. You'll need an under tank heater 1/3 the tank size with a thermostat, and possibly a ceramic heat emitter or a moonlight light bulb.
3) Anaolg thermometers are not very reliable. You will need a digital thermometer with a probe to measure ground temperatures. Also, you may use an infrared temperature gun.
4) It will need at least three hides. 1 warm dry hide. 1 humid hide 1 cool hide
5) Sand is not a good substrate for leopard geckos.(Some people use sand with success, but it can cause impaction) Textured slate tile is a better option, and plain old paper towel works well for young leopard geckos.
I'm just trying to save you some trouble down the road. Good luck!