Diet can replace supplementation! It's all about feeding a variety of healthy foods, but sometimes it'd difficult to do this with some reptiles. I attempt to go down this route, but in the end I still supplement very sparingly. This is how I go about it:
I use this as a guide for my feeders:
The Iguana Den - Iguana Diet - Grocery Guide
This diet is designed to give iguanas all of their vitamins and nutrients through their diet alone without any additional supplementation. Variety is the way to go. I also alternate it with a dry diet that is packed with nutrients. Unfortunately, the family who makes the feed I am currently using is discontinuing their product, but I am planning to use this next:
Kilgour's Chameleons - Cincinnati's Finest Panther Chameleons. It would be a good idea to get and additional feed as well to alternate with. I use Mazuri Hi Calcium Gut Load as my formal gut load once a week. It has vitamin D3 in it:
http://www.mazuri.com/product_pdfs/5M38.pdf. Variety is key!
I fill in gaps with minimal supplementation. In my opinion, it's better than playing the guessing game with supplements.