Okay, mine were from a similar situation to yours-- the adult female was one I brought in from outside, as is one of the "teenagers". The other "teen" was found at a plant shop wandering on a box, so we took her home. The two babies, as you all know, hatched in my adult's cage. The adult and teens were skittish initially, but never to the point of hiding all day. I made sure my movements around the cage were slow and predictable-- water bottles, masters, cricket dusting jars, etc. were all in view, so the geckos would eventually learn to associate each item with what came next. In less than a month, my WC adult female knew that crickets rattling in my glass vitamin dusting jar meant dinner-- and she'd come out into view as if to make sure she saw where those crickets went. The two younger ones didn't take long to make the association either, and now all of them will come to the front of their cages when they see me, because they associate me with food.
In regards to handling... The four youngsters are no problem, they'll regularly jump on us-- probably because we're warm-blooded and all. The adult female will tolerate our hands in the cage to move and clean things, but will run off if we move toward her with any sort of intent-- if that makes any sense. I anticipated this, so early on I fed her honey or crickets stuck to a wooden plank, like the kind you get for free from Home Depot to stir paint. I'd leave the plank there and stay to watch her eat a little, then walk away. When I needed to move her, I'd pick up the plank as soon as she started eating and move it to the other tank. Granted, she would panic a little, but never got to jump off in time. She's not used to being handled at all, and I'm not looking to change that-- but things still gotta get cleaned!
Forgot to add-- definitely get a front-opening tank, unless you're housing them at ground level. I have one of those "light trees" that's basically a pole with three bulb housings on it at different levels, so my girl gets heat and UVB through the side of her enclosure rather than the top.