#22---***GU's Mod Hilde on Calcium, Vitamin A, & D3 interactions, et cetera***
VITAMIN A:
: Promotes bone growth, teeth development.
: Helps form and maintain healthy skin, hair, mucous membranes.
: Builds body's resistance to respiratory infections.
: Essential for normal function of retina. Combines with purple pigment of retina (opsin) to form rhodopsin, which is necessary for sight in partial darkness.
: Necessary for proper testicular function, ovarian function, embryonic development, regulation of growth, differentiation of tissues.
VITAMIN D:
: Plays a key role in the absorption of calcium for bone and tooth development.
: Affects cardiovascular health, immune system, cancer prevention
: Has a major role in muscle development & strength
: Key role in mental health and depression avoidance
VITAMINS A & D interaction with other substances:
: Calcium decreases absorption of fat-soluble Vitamins A, D, E and K.
You can't see the Vitamin A shortage easily, except for possibly poor vision and/or aim when hunting. Rough skin is usually shrugged off as a 'bit of a bad shed' and hope it works better next time. If not.... well, we'll just remove the stuck skin with a cotton pad.
Lethargy and weakness might be chalked up to many things including boredom or brumation, never a thought that it could hint at a Vitamin D shortage.
CALCIUM - excess:
Excess calcium in the digestive tract can hinder absorption of Vitamin A and D (we won't worry about E & K here). MBD is often considered to be caused by a shortage of calcium, but can happen even though there is ample calcium available. If there's not enough Vit D available, either stored in the liver absorbed via food/supplements, then there won't be enough calcium absorbed. If you suspect a calcium shortage, it's easy to increase the amount available by dusting more often, even to the point of 'icing' the bugs with calcium, all of which just puts more calcium into the intestines but allowing less and less Vitamin A & D to be absorbed.... a vicious circle. The result is a gecko with possible MBD (even if it's on calcium substrate and gets calcium supplement), and a severe shortage of Vitamin A & D.
And so it continues.... more calcium, less vitamin A & D.
The next big worry is the next generation. The offspring of parents with Vitamin A and/or D imbalance can affect the young - they might hatch tiny, maybe shorter than normal tails, missing or deformed eyelids, a pouch-like flap of skin under the chin (looks like a tiny dewlap), weak, poor vision or even blind, weak or even deformed bones, including skull. It gets shrugged off as one of those things, after all, even in the wild they don't all hatch perfect.
Who would have thought that it could be traced to excess calcium?
Some people shy away from supplementing with pre-formed Vitamin A. It's been proven that geckos need it, they can't convert beta-carotene well enough to make do with just that. If the parents of your gecko were only supplemented with beta-carotene, no pre-formed Vit A, then they were prime candidates for a Vit A deficiency, and their offspring suffered the consequences. At the very least, add some pre-formed Vit A to the supplements a few times a month. Most can be beta-carotene, but the bit of pre-formed A will tide them over until they get enough beta-carotene converted."
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Related post #48 here: Can plain calcium carbonate be overdosed? Check link from post #5 onwards......
Leos having health issues,setup question
Edit: More info on post #48 can be provided if you wish.